Key Performance Ingredients
Endosomes: A liposome encapsulated extract from the marine microbe, Micrococcus Lysate. Extremely UV resistant, the extract contains the enzyme UV-endonuclease which improves the appearance of sun damaged skin.
Photolysomes: The liposome encapsulated DNA repair enzyme, photolyase derived from plankton, is hyper-efficient and unique in its ability to reduce the visible signs of UV-induced insults.
L’ergothioneine: A powerful antioxidant that fights oxidative damage caused by free radical activity.
Sodium Hyaluronate: A super humectant that deeply hydrates and binds up to 1,000 times its own weight in moisture, providing an immediate moisturizing boost.
Tocopheryl Acetate (Vitamin E): A natural antioxidant and moisturizer, reducing transdermal water loss and helping to maintain optimal moisture levels.
Ascorbyl Palmitate (Vitamin C): An effective free radical-scavenging antioxidant.
ACTIVE INGREDIENTS: Octinoxate 6.5%, Octisalate 2.5%, Zinc Oxide 8.5%. INACTIVE INGREDIENTS: Allantoin, Ascorbyl Palmitate, Butylene Glycol, Cetearyl Glucoside, Citric Acid, Cyclopentasiloxane, Dimethicone, Micrococcus Lysate, Plankton Extract, Ergothioneine, Ethyl Hexyl Isononanoate,Glycereth-26, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Iodopropynyl Butylcarbamate, Isopropyl Palmitate, Lecithin, Octyl Stearate, Oleth-3 Phosphate, Panthenol, PEG-7 Trimethylolpropane Coconut Ether, Phenoxyethanol, Polyether-1, Polyisobutene, Purified Water, Retinyl Palmitate, Sodium Hyaluronate, Sodium Hydroxide, Tocopheryl Acetate, Triethoxycaprylylsilane.
Reduced ultraviolet-induced DNA damage and apoptosis in human skin with topical application of a photolyase-containing DNA repair enzyme cream: Clues to Skin Cancer Prevention
ENZO BERARDESCA1, MARCO BERTONA2, KARMELA ALTABAS3, VELIMIR ALTABAS3 and ENZO EMANUELE2
1San Gallicano Dermatological Institute, IRCCS, Rome; 2Department of Health Sciences, University of Pavia, Pavia, Italy; 3Department of Internal Medicine, Clinical Hospital ‘Sestre Milosrdnice’, Zagreb, Croatia
STUDY OBJECTIVE Exposure of human skin to ultraviolet radiation (UVR) results in the formation of DNA damage that give rise to photoaging, mutations, cell death and the onset of carcinogenic (cancerous) events. Photolyase is a DNA repair enzyme that reverses damage caused by exposure to UVR. The study sought to investigate whether addition of photolyase enhances the protection provided by a traditional sunscreen (SS), by reducing the in vivo formation of destructive proteins and UVR-induced cell death in human skin.
STUDY DESIGN Ten volunteers (Fitzpatrick skin type II) were exposed to solar-simulated UVR at a three times minimal irritation dose for 4 consecutive days. Thirty minutes prior to each exposure, the test materials -- sunscreen alone, and sunscreen plus photolyase -- were applied topically to three different sites. One additional site was left untreated and one received exposure only. Biopsy specimens were taken 72 hours after the last irradiation and measured.
STUDY SIGNIFICANCE The data from this study suggest that the addition of photolyase to a traditional Sunscreen significantly improves the protection offered by topical creams against both UVR-induced DNA damage and cell death in the skin. Notably, the human model used in this study consisted of repeated UVR exposure. As the accumulation of residual DNA damage via repeated UVR exposure is deemed to play a key role in the development of skin cancer, the results clearly indicate that photolyase-containing topical preparations are superior to traditional sunscreens in reducing cancerous and pre-cancerous skin lesions as well as photoaging.
RESULTS & CONCLUSIONS The results not only confirm, but also substantially expand previous findings on the potential usefulness of photolyase for human photoprotection. It is known that the Photolyase plus sunscreen was superior to sunscreen alone. In conclusion, the addition of photolyase to a traditional sunscreen contributes significantly to the prevention of UVR-induced DNA damage and cell death when applied topically to human skin.