First, the answer is yes, retinol can make wrinkles worse, especially when you first start using it. What is happening is a drying effect, and one can get epidermal sliding from separation from the dermis. But this is temporary, and will eventually end up tightening the skin around the eyelids, provided you are using a potent retinol preparation.
Vitamin "A" serum, a retinaldehyde which is very similar to Retin-A (a prescription product) in efficacy but does not cause the irritation of Retin-A.
Researchers have found that heart-attack rates are rising for adults under age 40, climbing 2% every year for the last 10 years. They postulate the reason is younger patients are more likely to use marijuana and cocaine compared to slightly older counterparts, even if they drank less alcohol.