The glymphatic system (or glymphatic clearance pathway) is a functional waste clearance pathway for the mammalian central nervous system. The fact that the glymphatic system even exists is a recent finding, and one I did not learn in medical school.
However, we have come to understand that the brain’s glymphatic pathway is responsible for clearing harmful wastes – particularly amyloid-beta plaques that characterize Alzheimer’s Disease, during sleep.
As compared to sleeping on your back or stomach, sleeping on your side may help to clear brain waste.
From "Sleep" - "Employing an animal model, Helen Benveniste, from Stony Brook University (New York, USA), and colleagues studied the cerebrospinal fluid (CSF) - interstitial fluid (ISF) exchange efficiency – a marker of the clearance capacity of the glymphatic pathway. The team found that sleeping in the lateral position (on one’s side) may more effectively remove brain wastes including amyloid-beta, as compared to sleeping on the back or stomach. The study authors submit that: “We propose that the most popular sleep posture (lateral) has evolved to optimize waste removal during sleep.”
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First, the answer is yes, retinol can make wrinkles worse, especially when you first start using it. What is happening is a drying effect, and one can get epidermal sliding from separation from the dermis. But this is temporary, and will eventually end up tightening the skin around the eyelids, provided you are using a potent retinol preparation.