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The incidence of age-related diseases in a centenarian
offspring (children of parents who lived to be at least 97 years old) is
lower. The New England Centenarian Study (Massachusetts, USA) reported
that children of centenarians are at 78% lower risk of heart attack,
83% lower likelihood of stroke, and 86% lower risk of developing Type-2
diabetes. Additionally, centenarian offspring were 81% less likely to
die during the 5-year follow-up period (as compared to age-matched
While we cannot choose our parents, we can acknowledge that genetics do factor in to longevity. Centenarian offspring are more likely to age in better cardiovascular health and with a lower mortality than their peers, suggesting that anti-aging science still has yet to reveal keys to the physiological reasons that longevity runs in families.
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First, the answer is yes, retinol can make wrinkles worse, especially when you first start using it. What is happening is a drying effect, and one can get epidermal sliding from separation from the dermis. But this is temporary, and will eventually end up tightening the skin around the eyelids, provided you are using a potent retinol preparation.