Kinston University (United Kingdom) researchers reported in 2005 that an unmade bed, while unattractive to the eyes, is unappealing to house dust mites, tiny bugs (shorter than 1 mm long) that feed on shed human skin cells and produce excretions that, when inhaled by people, can cause allergic reactions and asthma.
According to the team, the average bed can house as many as 1.5 million dust mites. When a bed is made immediately or shortly after people get out of it, moisture can become trapped in the sheets and mattress, creating a haven for the mites. Moisture is minimized in unmade beds, and as a result the mites will more be more likely to dehydrate and die than feast and multiply.
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First, the answer is yes, retinol can make wrinkles worse, especially when you first start using it. What is happening is a drying effect, and one can get epidermal sliding from separation from the dermis. But this is temporary, and will eventually end up tightening the skin around the eyelids, provided you are using a potent retinol preparation.